A recent CDC analysis shows that antihistamines, particularly first-generation H1 subtype antihistamines like diphenhydramine, play a role in drug overdoses. Opioids were involved in most cases, and naloxone may not work with antihistamines. Continual monitoring is important.
For over two decades, the opioid crisis in the United States has been an urgent health care emergency. Initially driven by over-prescription of pharmaceutical opioids, this has evolved into a “fourth wave” marked by poly-substance use, combining opioids and methamphetamine, resulting in record-high deaths year after year. The Covid-19 pandemic has made the situation even