Drug Safety & Efficacy

What the 2021 Guidelines Actually Changed About Clindamycin

A CE Dojo clinical note A claim keeps circulating in dental circles: clindamycin has no role in dentistry anymore, it’s been pulled from the formulary, there’s no reason to use it. It gets repeated with confidence, usually pointing at the 2021 AHA and ADA update. The confidence is the problem, because the claim folds two […]

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Caldwell Syndrome

In 2011, Lesley Yates, a dedicated mother and teacher’s aide, faced a life-altering ordeal when a routine antibiotic prescription led to severe tendon injuries, ultimately forcing her into premature disability at 54. Her harrowing experience underscores the dark side of fluoroquinolone antibiotics, spotlighting not only the well-documented risks of tendon ruptures but also the profound

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CBD For Dental Pain In Place Of NSAIDS

A randomized controlled study has demonstrated that cannabidiol (CBD) may serve as an effective alternative to nonsteroidal anti-inflammatory drugs (NSAIDs) for managing acute dental pain, particularly beneficial for patients unable to tolerate NSAIDs. The research, led by Vanessa Chrepa, PhD, DDS, MS from UT Health San Antonio, involved adults with moderate to severe dental pain,

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FDA Modernization Act 2.0

Congress has passed the FDA Modernization Act 2.0 as part of the recent omnibus bill, removing the requirement to use animal testing in drug development. This allows drug companies to use alternative safety-testing models, such as cell-based assays, organ chips and microphysiological systems, and sophisticated computer modeling. Proponents state these alternatives are cost-effective and provide

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